Publications | The Keku Lab

2018

An Aberrant Microbiota is not Strongly Associated with Incidental Colonic Diverticulosis.

Roshonda B. Jones, Anthony A. Fodor, Anne F. Peery, Matthew C. B. Tsilimigras, Kathryn Winglee, Amber McCoy, Michael Sioda, Robert S. Sandler & Temitope O. Keku

Scientific Reports, 2018

PMID: 29563543

Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors.

Evan L. Busch, Prabhani Kuruppumullage Don, Haitao Chu, David B. Richardson, Temitope O. Keku, David A. Eberhard , Christy L. Avery and Robert S. Sandler

BMC Cancer, 2018

PMID: 29338703

Maternal Gut Microbiome Biodiversity in Pregnancy.

Smid MC, Ricks NM, Panzer A, Mccoy AN, Azcarate-Peril MA, Keku TO, Boggess KA

American Journal of Perinatology, 2018

PMID: 28750469

2017

Colonic Diverticula Are Not Associated With Mucosal Inflammation or Chronic Gastrointestinal Symptoms.

Peery AF, Keku TO, Addamo C, McCoy AN, Martin CF, Galanko JA, Sandler RS

Clincal Gastroenterology and Hepatology, 2017

PMID: 28603053

Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

Wang H, Schmit SL, Haiman CA, Keku TO, Kato I, Palmer JR, van den Berg D, Wilkens LR, Burnett T, Conti DV, Schumacher FR, Signorello LB, Blot WJ, Zanetti KA, Harris C, Pande M, Berndt SI, Newcomb PA, West DW, Haile R, Stram DO, Figueiredo JC; Hispanic Colorectal Cancer Study, Le Marchand L

International Journal of Cancer, 2017

PMID: 28295283

Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development.

Ren NSX, Ji M, Tokar EJ, Busch EL, Xu X, Lewis D, Li X, Jin A, Zhang Y, Wu WKK, Huang W, Li L, Fargo DC, Keku TO, Sandler RS, Li X

Current Biology, 2017

PMID: 28162896

2016

Distribution and Characteristics of Colonic Diverticula in a United States Screening Population.

Peery AF, Keku TO, Martin CF, Eluri S, Runge T, Galanko JA, Sandler RS

Clinical Gastroenterology and Hepatology, 2016

PMID: 26872402

Evaluating markers of epithelial-mesenchymal transition to identify cancer patients at risk for metastatic disease.

Busch EL, Keku TO, Richardson DB, Cohen SM, Eberhard DA, Avery CL, Sandler RS

Clinical and Experimental Metastasis, 2016

PMID: 26507436

2015

Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans.

Wang H, Iwasaki M, Haiman CA, Kono S, Wilkens LR, Keku TO, Berndt SI, Tsugane S, Le Marchand L

PLoS One, 2015

PMID: 26683305

The Gastrointestinal Microbiota and Colorectal Cancer.

Keku TO, Dulal S, Deveaux A, Jovov B, Han X.

Am J Physiol Gastrointest Liver Physiol. 2014

PMID: 25540232

2014

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.

Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, Loo LW, Van Den Berg D, Kolonel LN, Henderson BE, Keku TO, Sandler RS, Signorello LB, Blot WJ, Newcomb PA, Pande M, Amos CI, West DW, Bézieau S, Berndt SI, Zanke BW, Hsu L; Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Lindor NM, Haile RW, Hopper JL, Jenkins MA, Gallinger S, Casey G; Colon Cancer Family Registry (CCFR), Stenzel SL, Schumacher FR, Peters U, Gruber SB; Colorectal Transdisciplinary Study (CORECT), Tsugane S, Stram DO, Le Marchand L.

Nat Commun. 2014 Aug 8;5:4613.

PMID: 25105248

Gut microbiome and colorectal adenomas.

Dulal S, Keku TO.

Cancer J. 2014 May-Jun;20(3):225-31.

PMID: 24855012

Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas.

Nugent JL, McCoy AN, Addamo CJ, Jia W, Sandler RS, Keku TO.

J Proteome Res. 2014 Apr 4;13(4):1921-9.

PMID: 24601673

Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk.

Santoro MA, Andres SF, Galanko JA, Sandler RS, Keku TO, Lund PK.

Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):2093-100. doi: 10.1158/1055-9965.EPI-14-0177. Epub 2014 Jul 13.

PMID: 25017244

Shared and independent colorectal cancer risk alleles in TGFβ-related genes in African and European Americans.

Kupfer SS, Skol AD, Hong E, Ludvik A, Kittles RA, Keku TO, Sandler RS, Ellis NA.

Carcinogenesis. 2014 Sep;35(9):2025-30. doi: 10.1093/carcin/bgu088. Epub 2014 Apr 21.

PMID: 24753543

Influence of race on microsatellite instability and CD8+ T cell infiltration in colon cancer.

Carethers JM, Murali B, Yang B, Doctolero RT, Tajima A, Basa R, Smith EJ, Lee M, Janke R, Ngo T, Tejada R, Ji M, Kinseth M, Cabrera BL, Miyai K, Keku TO, Martin CF, Galanko JA, Sandler RS, McGuire KL.

PLoS One. 2014 Jun 23;9(6):e100461.

PMID: 24956473

Nucleotide excision repair gene polymorphisms, meat intake and colon cancer risk.

Steck SE, Butler LM, Keku T, Antwi S, Galanko J, Sandler RS, Hu JJ.

Mutat Res Fundam Mol Mech Mutagen. 2014 Apr;762:24-31.

PMID: 24607854

Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans.

Pibiri F, Kittles RA, Sandler RS, Keku TO, Kupfer SS, Xicola RM, Llor X, Ellis NA.

Cancer Causes Control. 2014 May;25(5):561-70.

PMID: 24562971

2013

Fusobacterium spp. and colorectal cancer: cause or consequence?

Keku TO, McCoy AN, Azcarate-Peril AM.

Trends Microbiol. 2013 Oct;21(10):506-8.

PMID: 24029382

Somatic gene mutations in African Americans may predict worse outcomes in colorectal cancer.

Kang M, Shen XJ, Kim S, Araujo-Perez F, Galanko JA, Martin CF, Sandler RS, Keku TO.

Cancer Biomark. 2013;13(5):359-66.

PMID: 24440976

Fusobacterium is associated with colorectal adenomas.

McCoy AN, Araújo-Pérez F, Azcárate-Peril A, Yeh JJ, Sandler RS, Keku TO.

PLoS One. 2013;8(1):e53653.

PMID: 23335968

Association of plasma endotoxin, inflammatory cytokines and risk of colorectal adenomas.

Kang M, Edmundson P, Araujo-Perez F, McCoy AN, Galanko J, Keku TO.

BMC Cancer. 2013 Feb 26;13:91.

PMID: 23442743

Plasma insulin, glucose, IGF-I, IGF-II, and IGFBP-3 and risk of recurrent colorectal adenomas.

Kang M, Peery AF, Locklear C, Galanko JA, Sandler RS, Keku TO.

J Gastroenterol Hepatol Res. 2013 Apr 14;2(4):531-535.

PMID: 24533351

Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans.

Wang H, Haiman CA, Burnett T, Fortini BK, Kolonel LN, Henderson BE, Signorello LB, Blot WJ, Keku TO, Berndt SI, Newcomb PA, Pande M, Amos CI, West DW, Casey G, Sandler RS, Haile R, Stram DO, Le Marchand L.

Hum Mol Genet. 2013 Dec 15;22(24):5048-55.

PMID: 23851122

2012

Differential gene expression between African American and European American colorectal cancer patients.

Jovov B, Araujo-Perez F, Sigel CS, Stratford JK, McCoy AN, Yeh JJ, Keku T.

PLoS One. 2012;7(1):e30168.

PMID: 22276153

Intestinal inflammation targets cancer-inducing activity of the microbiota.

Arthur JC, Perez-Chanona E, Mühlbauer M, Tomkovich S, Uronis JM, Fan TJ, Campbell BJ, Abujamel T, Dogan B, Rogers AB, Rhodes JM, Stintzi A, Simpson KW, Hansen JJ, Keku TO, Fodor AA, Jobin C.

Science. 2012 Oct 5;338(6103):120-3.

PMID: 22903521

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans.

Sanapareddy N, Legge RM, Jovov B, McCoy A, Burcal L, Araujo-Perez F, Randall TA, Galanko J, Benson A, Sandler RS, Rawls JF, Abdo Z, Fodor AA, Keku TO.

ISME J. 2012 Oct;6(10):1858-68.

PMID: 22622349

Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa.

Vidal AC, Lund PK, Hoyo C, Galanko J, Burcal L, Holston R, Massa B, Omofoye O, Sandler RS, Keku TO.

BMC Cancer. 2012 Sep 5;12:389.

PMID: 22950808

Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.

Hoskins JM, Ong PS, Keku TO, Galanko JA, Martin CF, Coleman CA, Wolfe M, Sandler RS, McLeod HL.

PLoS One. 2012;7(7):e41954.

PMID: 22848671

Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.

Keku TO, Vidal A, Oliver S, Hoyo C, Hall IJ, Omofoye O, McDoom M, Worley K, Galanko J, Sandler RS, Millikan R.

Cancer Causes Control. 2012 Jul;23(7):1127-38.

PMID: 22565227

Differences in microbial signatures between rectal mucosal biopsies and rectal swabs.

Araújo-Pérez F, McCoy AN, Okechukwu C, Carroll IM, Smith KM, Jeremiah K, Sandler RS, Asher GN, Keku TO.

Gut Microbes. 2012 Nov-Dec;3(6):530-5.

PMID: 23060016

IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites.

Hoyo C, Murphy SK, Schildkraut JM, Vidal AC, Skaar D, Millikan RC, Galanko J, Sandler RS, Jirtle R, Keku T.

Dis Markers. 2012;32(2):133-41.

PMID: 22377707

The case-only independence assumption: associations between genetic polymorphisms and smoking among controls in two population-based studies.

Hodgson ME, Olshan AF, North KE, Poole CL, Zeng D, Tse CK, Keku TO, Galanko J, Sandler R, Millikan RC.

Int J Mol Epidemiol Genet. 2012;3(4):333-60. Epub 2012 Nov 15.

PMID: 23205185

Markers of tyrosine kinase activity in eosinophilic esophagitis: a pilot study of the FIP1L1-PDGFRα fusion gene, pERK 1/2, and pSTAT5.

Dellon ES, Bower JJ, Keku TO, Chen X, Miller CR, Woosley JT, Orlando RC, Shaheen NJ.

Dis Esophagus. 2012 Feb;25(2):166-74.

PMID: 21819482

Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.

Tuupanen S, Yan J, Turunen M, Gylfe AE, Kaasinen E, Li L, Eng C, Culver DA, Kalady MF, Pennison MJ, Pasche B, Manne U, de la Chapelle A, Hampel H, Henderson BE, Le Marchand L, Hautaniemi S, Askhtorab H, Smoot D, Sandler RS, Keku T, Kupfer SS, Ellis NA, Haiman CA, Taipale J, Aaltonen LA.

Cancer Genet. 2012 Jan-Feb;205(1-2):25-33.

PMID: 22429595

Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.

Tippin BL, Levine AJ, Materi AM, Song WL, Keku TO, Goodman JE, Sansbury LB, Das S, Dai A, Kwong AM, Lin AM, Lin JM, Park JM, Patterson RE, Chlebowski RT, Garavito RM, Inoue T, Cho W, Lawson JA, Kapoor S, Kolonel LN, Le Marchand L, Haile RW, Sandler RS, Lin HJ.

Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):22-8.

PMID: 21821144

2011

Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome.

Carroll IM, Ringel-Kulka T, Keku TO, Chang YH, Packey CD, Sartor RB, Ringel Y.

Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G799-807.

PMID: 21737778

Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis.

Uronis JM, Arthur JC, Keku T, Fodor A, Carroll IM, Cruz ML, Appleyard CB, Jobin C.

Inflamm Bowel Dis. 2011 Jan;17(1):289-97.

PMID: 20564535

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.

Stacey SN, Sulem P, Jonasdottir A, Masson G, Gudmundsson J, Gudbjartsson DF, Magnusson OT, Gudjonsson SA, Sigurgeirsson B, Thorisdottir K, Ragnarsson R, Benediktsdottir KR, Nexø BA, Tjønneland A, Overvad K, Rudnai P, Gurzau E, Koppova K, Hemminki K, Corredera C, Fuentelsaz V, Grasa P, Navarrete S, Fuertes F, García-Prats MD, Sanambrosio E, Panadero A, De Juan A, Garcia A, Rivera F, Planelles D, Soriano V, Requena C, Aben KK, van Rossum MM, Cremers RG, van Oort IM, van Spronsen DJ, Schalken JA, Peters WH, Helfand BT, Donovan JL, Hamdy FC, Badescu D, Codreanu O, Jinga M, Csiki IE, Constantinescu V, Badea P, Mates IN, Dinu DE, Constantin A, Mates D, Kristjansdottir S, Agnarsson BA, Jonsson E, Barkardottir RB, Einarsson GV, Sigurdsson F, Moller PH, Stefansson T, Valdimarsson T, Johannsson OT, Sigurdsson H, Jonsson T, Jonasson JG, Tryggvadottir L, Rice T, Hansen HM, Xiao Y, Lachance DH, O Neill BP, Kosel ML, Decker PA, Thorleifsson G, Johannsdottir H, Helgadottir HT, Sigurdsson A, Steinthorsdottir V, Lindblom A; Swedish Low-risk Colorectal Cancer Study Group, Sandler RS, Keku TO, Banasik K, Jørgensen T, Witte DR, Hansen T, Pedersen O, Jinga V, Neal DE, Catalona WJ, Wrensch M, Wiencke J, Jenkins RB, Nagore E, Vogel U, Kiemeney LA, Kumar R, Mayordomo JI, Olafsson JH, Kong A, Thorsteinsdottir U, Rafnar T, Stefansson K.

Nat Genet. 2011 Sep 25;43(11):1098-103.

PMID: 21946351

Genetic associations in the vitamin D receptor and colorectal cancer in African Americans and Caucasians.

Kupfer SS, Anderson JR, Ludvik AE, Hooker S, Skol A, Kittles RA, Keku TO, Sandler RS, Ruiz-Ponte C, Castellvi-Bel S, Castells A, Carracedo A, Ellis NA.

PLoS One. 2011;6(10):e26123.

PMID: 22046258

2010

Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas.

Shen XJ, Rawls JF, Randall T, Burcal L, Mpande CN, Jenkins N, Jovov B, Abdo Z, Sandler RS, Keku TO.

Gut Microbes. 2010 May-Jun;1(3):138-47.

PMID: 20740058

Associations of red meat, fat, and protein intake with distal colorectal cancer risk.

Williams CD, Satia JA, Adair LS, Stevens J, Galanko J, Keku TO, Sandler RS.

Nutr Cancer. 2010;62(6):701-9.

PMID: 20661817

Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk.

Hamilton KE, Lund PK, Galanko JA, Sandler RS, Keku TO.

BMC Res Notes. 2010 May 25;3:144.

PMID: 20500855

Antioxidant and DNA methylation-related nutrients and risk of distal colorectal cancer.

Williams CD, Satia JA, Adair LS, Stevens J, Galanko J, Keku TO, Sandler RS.

Cancer Causes Control. 2010 Aug;21(8):1171-81.

PMID: 20352485

Relationship of EMAST and microsatellite instability among patients with rectal cancer.

Devaraj B, Lee A, Cabrera BL, Miyai K, Luo L, Ramamoorthy S, Keku T, Sandler RS, McGuire KL, Carethers JM.

J Gastrointest Surg. 2010 Oct;14(10):1521-8.

PMID: 20844976

Genetic heterogeneity in colorectal cancer associations between African and European americans.

Kupfer SS, Anderson JR, Hooker S, Skol A, Kittles RA, Keku TO, Sandler RS, Ellis NA.

Gastroenterology. 2010 Nov;139(5):1677-85, 1685.e1-8.

PMID: 20659471

2009

The association between diabetes, insulin use, and colorectal cancer among Whites and African Americans.

Vinikoor LC, Long MD, Keku TO, Martin CF, Galanko JA, Sandler RS.

Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1239-42.

PMID: 19336553

Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.

Hoyo C, Grubber J, Demark-Wahnefried W, Lobaugh B, Jeffreys AS, Grambow SC, Marks JR, Keku TO, Walther PJ, Schildkraut JM.

J Natl Med Assoc. 2009 Jul;101(7):711-6.

PMID: 19634593

Dietary patterns, food groups, and rectal cancer risk in Whites and African-Americans.

Williams CD, Satia JA, Adair LS, Stevens J, Galanko J, Keku TO, Sandler RS.

Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1552-61.

PMID: 19423533

Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review.

Taioli E, Garza MA, Ahn YO, Bishop DT, Bost J, Budai B, Chen K, Gemignani F, Keku T, Lima CS, Le Marchand L, Matsuo K, Moreno V, Plaschke J, Pufulete M, Thomas SB, Toffoli G, Wolf CR, Moore CG, Little J.

Am J Epidemiol. 2009 Nov 15;170(10):1207-21.

PMID: 19846566

2008

Assessment of serum proteomics to detect large colon adenomas.

Ransohoff DF, Martin C, Wiggins WS, Hitt BA, Keku TO, Galanko JA, Sandler RS.

Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2188-93.

PMID: 18708413

Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas.

Keku TO, Sandler RS, Simmons JG, Galanko J, Woosley JT, Proffitt M, Omofoye O, McDoom M, Lund PK.

BMC Cancer. 2008 May 22;8:143.

PMID: 18498652

Circulating levels of inflammatory cytokines and risk of colorectal adenomas.

Kim S, Keku TO, Martin C, Galanko J, Woosley JT, Schroeder JC, Satia JA, Halabi S, Sandler RS.

Cancer Res. 2008 Jan 1;68(1):323-8. doi:

PMID: 18172326

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.

Yeh JJ, Routh ED, Rubinas T, Peacock J, Martin TD, Shen XJ, Sandler RS, Kim HJ, Keku TO, Der CJ.

Mol Cancer Ther. 2009 Apr;8(4):834-43.

PMID: 19372556

Apoptosis in normal rectal mucosa, baseline adenoma characteristics, and risk of future adenomas.

Keku TO, Amin A, Galanko J, Martin C, Schliebe B, Sandler RS.

Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):306-10.

PMID: 18268113

Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study.

Butler LM, Millikan RC, Sinha R, Keku TO, Winkel S, Harlan B, Eaton A, Gammon MD, Sandler RS.

Mutat Res. 2008 Feb 1;638(1-2):162-74. Epub 2007 Oct 13.

PMID: 18022202

Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.

Steck SE, Keku T, Butler LM, Galanko J, Massa B, Millikan RC, Sandler RS.

J Nutrigenet Nutrigenomics. 2008;1(4):196-204.

PMID: 19776626

Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans.

Kim S, Martin C, Galanko J, Woosley JT, Schroeder JC, Keku TO, Satia JA, Halabi S, Sandler RS.

Am J Epidemiol. 2008 Dec 1;168(11):1292-300.

PMID: 18945689

Statistical strategies to improve the efficiency of molecular studies of colorectal cancer prognosis.

Qu P, Chu H, Ibrahim JG, Peacock J, Shen XJ, Tepper J, Sandler RS, Keku TO.

Br J Cancer. 2008 Dec 16;99(12):2001-5.

PMID: 19018265

Pre-2008

RNA expression analysis of formalin-fixed paraffin-embedded tumors.

Penland SK, Keku TO, Torrice C, He X, Krishnamurthy J, Hoadley KA, Woosley JT, Thomas NE, Perou CM, Sandler RS, Sharpless NE.

Lab Invest. 2007 Apr;87(4):383-91. Epub 2007 Feb 12.

PMID: 17297435

Calcium, dietary, and lifestyle factors in the prevention of colorectal adenomas.

Miller EA, Keku TO, Satia JA, Martin CF, Galanko JA, Sandler RS.

Cancer. 2007 Feb 1;109(3):510-7.

PMID: 17200965

Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers.

Jung B, Smith EJ, Doctolero RT, Gervaz P, Alonso JC, Miyai K, Keku T, Sandler RS, Carethers JM.

Int J Cancer. 2006 May 15;118(10):2509-13.

PMID: 16380996

Gastric cancer and the high combination prevalence of host cytokine genotypes and Helicobacter pylori in Honduras.

Morgan DR, Dominguez RL, Keku TO, Heidt PE, Martin CF, Galanko JA, Omofoye OA, Sandler RS.

Clin Gastroenterol Hepatol. 2006 Sep;4(9):1103-11. Epub 2006 Jul 3.

PMID: 16820326

COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States).

Sansbury LB, Millikan RC, Schroeder JC, North KE, Moorman PG, Keku TO, de Cotret AR, Player J, Sandler RS.

Cancer Causes Control. 2006 Apr;17(3):257-66.

PMID: 16489533

Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study.

Mechanic LE, Millikan RC, Player J, de Cotret AR, Winkel S, Worley K, Heard K, Heard K, Tse CK, Keku T.

Carcinogenesis. 2006 Jul;27(7):1377-85. Epub 2006 Jan 6.

PMID: 16399771

Insulin resistance, apoptosis, and colorectal adenoma risk.

Keku TO, Lund PK, Galanko J, Simmons JG, Woosley JT, Sandler RS.

Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2076-81.

PMID: 16172212

5,10-methylenetetrahydrofolate reductase 677 and 1298 polymorphisms, folate intake, and microsatellite instability in colon cancer.

Eaton AM, Sandler R, Carethers JM, Millikan RC, Galanko J, Keku TO.

Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2023-9.

PMID: 16103455

Diet, lifestyle, and genomic instability in the North Carolina Colon Cancer Study.

Satia JA, Keku T, Galanko JA, Martin C, Doctolero RT, Tajima A, Sandler RS, Carethers JM.

Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):429-36.

PMID: 15734969

Calcium, vitamin D, and apoptosis in the rectal epithelium.

Miller EA, Keku TO, Satia JA, Martin CF, Galanko JA, Sandler RS.

Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):525-8.

PMID: 15734982

Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk.

Millikan RC, Player JS, Decotret AR, Tse CK, Keku T.

Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2326-34.

PMID: 16214912

Does physical activity modify the association between body mass index and colorectal adenomas?

Guilera M, Connelly-Frost A, Keku TO, Martin CF, Galanko J, Sandler RS.

Nutr Cancer. 2005;51(2):140-5.

PMID: 15860435

Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites.

Millikan RC, Player J, de Cotret AR, Moorman P, Pittman G, Vannappagari V, Tse CK, Keku T.

Breast Cancer Res. 2004;6(4):R264-74. Epub 2004 Apr 7.

PMID: 15217492

Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers.

Jung B, Doctolero RT, Tajima A, Nguyen AK, Keku T, Sandler RS, Carethers JM.

Gastroenterology. 2004 Mar;126(3):654-9.

PMID: 14988818

Gene testing: what the health professional needs to know.

Keku TO, Rakhra-Burris T, Millikan R.

J Nutr. 2003 Nov;133(11 Suppl 1):3754S-3757S. Review.

PMID: 14608110

Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer.

Shaheen NJ, Silverman LM, Keku T, Lawrence LB, Rohlfs EM, Martin CF, Galanko J, Sandler RS.

J Natl Cancer Inst. 2003 Jan 15;95(2):154-9.

PMID: 12529348

Family history of colon cancer: what does it mean and how is it useful?

Keku TO, Millikan RC, Martin C, Rahkra-Burris TK, Sandler RS.

Am J Prev Med. 2003 Feb;24(2):170-6.

PMID: 12568823

Vitamin C intake and apoptosis in normal rectal epithelium.

Connelly AE, Satia-Abouta J, Martin CF, Keku TO, Woosley JT, Lund PK, Sandler RS.

Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):559-65.

PMID: 12815003

5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites.

Keku T, Millikan R, Worley K, Winkel S, Eaton A, Biscocho L, Martin C, Sandler R.

Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1611-21.

PMID: 12496052

IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts.

Simmons JG, Pucilowska JB, Keku TO, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2002 Sep;283(3):G809-18.

PMID: 12181198

Nonsteroidal anti-inflammatory drugs, apoptosis, and colorectal adenomas.

Martin C, Connelly A, Keku TO, Mountcastle SB, Galanko J, Woosley JT, Schliebe B, Lund PK, Sandler RS.

Gastroenterology. 2002 Dec;123(6):1770-7.

PMID: 12454832

Reduction of spontaneous and irradiation-induced apoptosis in small intestine of IGF-I transgenic mice.

Wilkins HR, Ohneda K, Keku TO, D’Ercole AJ, Fuller CR, Williams KL, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2002 Aug;283(2):G457-64.

PMID: 12121894

Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia.

Lin HJ, Lakkides KM, Keku TO, Reddy ST, Louie AD, Kau IH, Zhou H, Gim JS, Ma HL, Matthies CF, Dai A, Huang HF, Materi AM, Lin JH, Frankl HD, Lee ER, Hardy SI, Herschman HR, Henderson BE, Kolonel LN, Le Marchand L, Garavito RM, Sandler RS, Haile RW, Smith WL.

Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1305-15.

PMID: 12433707

Rectal mucosal proliferation, dietary factors, and the risk of colorectal adenomas.

Keku TO, Galanko JA, Murray SC, Woosley JT, Sandler RS.

Cancer Epidemiol Biomarkers Prev. 1998 Nov;7(11):993-9.

PMID: 9829707

In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.

Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS, Brenner DA.

Gastroenterology. 1997 Nov;113(5):1589-98.

PMID: 9352861

The in vitro HL-60 cell–Trypanosoma brucei rhodesiense culture system: a rapid in vitro drug screen.

Keku TO, Seed JR, Tidwell RR.